There are a lot of official studies going on and sowing how well this all works, and will hopefully start to become legal and official soon. In the meantime you can still go it alone if you're sure and careful. With Ayahuasca you have to be off medication though, not even supplements, and have to change your diet in the lead up to taking it.

Keep doing research though and in the end, it has to be up to you. Feel free to ask any questions and I'll answer if I can.